Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein.

abstract

• The nucleotide and deduced amino acid sequences of the phosphoprotein (P) mRNA of bovine respiratory syncytial virus (BRSV) strain A51908 have been determined. The P mRNA is 860 nucleotides long with a single large open reading frame and the encoded polypeptide is 241 amino acids long. Comparison with the corresponding sequences of human respiratory syncytial virus (HRSV) subgroups A and B revealed 72 to 74% identity at the nucleotide level, and 81% at the amino acid level. The P protein contains a single divergent domain (37% amino acid identity) flanked by highly conserved domains (87% amino acid identity). The 3' end non-coding region is 47 nucleotides shorter than the corresponding region of HRSV. Comparison of the P mRNA sequences of two strains of BRSV (A51908 and FS-1) showed that there was extensive sequence identity at both the nucleotide (97%) and amino acid (97.9%) levels.

authors

• Reddy, Sanjay

published proceedings

• J Gen Virol

altmetric score

• 3

author list (cited authors)

• Mallipeddi, S. K., & Samal, S. K

citation count

• 17

complete list of authors

• Mallipeddi, SK||Samal, SK

publication date

• September 1992

publisher

• Microbiology Society  Publisher

published in

• JOURNAL OF GENERAL VIROLOGY  Journal

keywords

• Amino Acid Sequence
• Animals
• Antigens, Viral
• Base Sequence
• Cattle
• Genetic Variation
• Hn Protein
• Humans
• Molecular Sequence Data
• Phosphoproteins
• RNA, Messenger
• Respiratory Syncytial Viruses
• Sequence Homology, Nucleic Acid
• Viral Envelope Proteins
• Viral Proteins

PubMed Central ID

• 1402819

Digital Object Identifier (DOI)

• 10.1099/0022-1317-73-9-2441

start page

• 2441

end page

• 2444

volume

• 73 ( Pt 9)

issue

• 9

URL

• http://dx.doi.org/10.1099/0022-1317-73-9-2441