Increased interleukin-6 activity in the serum of ponies acutely infected with equine infectious anaemia virus. Academic Article

abstract

• Seven ponies were infected with the virulent wild-type Wyoming strain of equine infectious anaemia virus (EIAV). Infection status was monitored by serum reverse transcriptase activity, rectal temperature, and complete blood count. Preinfection serum and serum obtained during the initial febrile episode following infection were assayed for interleukin 6 (IL-6) activity. Postinfection IL-6 activity was significantly increased as compared to preinfection values. The magnitude of increase in IL-6 was positively correlated with reverse transcriptase activity (an indirect measure of viraemia) but was not correlated with rectal temperature. IL-6 production in response to EIAV infection may play a role in pathogenesis of disease, especially the hyperglobulinaemia and apparent polyclonal B cell activation in these horses.

authors

• Russell, Karen

published proceedings

• Res Vet Sci

author list (cited authors)

• Sellon, D. C., Russell, K. E., Monroe, V. L., & Walker, K. M.

citation count

• 8

complete list of authors

• Sellon, DC||Russell, KE||Monroe, VL||Walker, KM

publication date

• February 1999

publisher

• Elsevier  Publisher

published in

• Research in Veterinary Science  Journal

keywords

• Animals
• Body Temperature
• Equine Infectious Anemia
• Horses
• Interleukin-6
• Lentivirus
• RNA-Directed DNA Polymerase
• Time Factors
• Virulence

PubMed Central ID

• 10088717

Digital Object Identifier (DOI)

• 10.1053/rvsc.1998.0245

start page

• 77

end page

• 80

volume

• 66

issue

• 1

URL

• http://dx.doi.org/10.1053/rvsc.1998.0245

user-defined tag

• 3 Good Health and Well-Being