Porphyrin Immobilized Nanographene Oxide for Enhanced and Targeted Photothermal Therapy of Brain Cancer.
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Brain cancer is a fatal disease that is difficult to treat because of poor targeting and low permeability of chemotherapeutic drugs through the blood brain barrier. In a comparison to current treatments, such as surgery followed by chemotherapy and/or radiotherapy, photothermal therapy is a remarkable noninvasive therapy developed in recent years. In this work, porphyrin immobilized nanographene oxide (PNG) was synthesized and bioconjugated with a peptide to achieve enhanced and targeted photothermal therapy for brain cancer. PNG was dispersed into the agar based artificial tissue model and demonstrated a photo-to-thermal conversion efficiency of 19.93% at a PNG concentration of only 0.5 wt %, with a heating rate of 0.6 C/s at the beginning of irradiation. In comparison, 0.5 wt % graphene oxide (GO) indicated a photo-to-thermal conversion efficiency of 12.20% and a heating rate of 0.3 C/s. To actively target brain tumor cells without harming healthy cells and tissues surrounding the laser path, a tripeptide l-arginyl-glycyl-l-aspartic (RGD) was further grafted to PNG. The photothermal therapy effects of PNG-RGD completely eliminated the tumor in vivo, indicating its excellent therapeutic effect for the treatment of brain cancer.
author list (cited authors)
Su, S., Wang, J., Vargas, E., Wei, J., Martnez-Zaguiln, R., Sennoune, S. R., ... Qiu, J.
complete list of authors
Su, Siheng||Wang, Jilong||Vargas, Evan||Wei, Junhua||Martínez-Zaguilán, Raul||Sennoune, Souad R||Pantoya, Michelle L||Wang, Shiren||Chaudhuri, Jharna||Qiu, Jingjing