Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen. Academic Article

abstract

• The effect of the selenium-containing compounds selenomethionine, selenocystine and ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] on the oxidation of dihydrorhodamine 123 caused by peroxynitrite and on the nitration of 4-hydroxyphenylacetate by peroxynitrite was studied in comparison with their sulphur analogues methionine, cystine and ebsulfur [2-phenyl-1,2-benzisothiazol-3(2H)-one]. The selenocompounds protected dihydrorhodamine 123 from oxidation and 4-hydroxyphenylacetate from nitration more effectively than their sulphur analogues. Sodium selenite exhibited no effect. These observations are corollaries to the recent finding [Roussyn, Briviba, Masumoto and Sies (1996) Arch. Biochem. Biophys. 330, 216-218] that selenium-containing compounds are efficient in protecting against peroxynitrite-induced DNA single-strand breaks.

authors

• Rusyn, Ivan

published proceedings

• Biochem J

author list (cited authors)

• Briviba, K., Roussyn, I., Sharov, V. S., & Sies, H.

citation count

• 113

complete list of authors

• Briviba, K||Roussyn, I||Sharov, VS||Sies, H

publication date

• October 1996

publisher

• Portland Press  Publisher

published in

• Biochemical Journal  Journal

keywords

• Azoles
• Cystine
• Isoindoles
• Kinetics
• Nitrates
• Organoselenium Compounds
• Oxidation-Reduction
• Phenylacetates
• Rhodamines
• Selenomethionine

PubMed Central ID

• 8870642

Digital Object Identifier (DOI)

• 10.1042/bj3190013

start page

• 13

end page

• 15

volume

• 319 ( Pt 1)

issue

• Pt 1

URL

• http://dx.doi.org/10.1042/bj3190013