Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Academic Article uri icon

abstract

  • This study used tissue samples from male B6C3F1 mice treated with ethanol in drinking water (0%, 2.5%, or 5%) for 4 or 104 weeks. We tested whether chronic alcohol drinking promotes oxidative stress in the liver and characterized the mutation profile of spontaneous and ethanol-induced tumors. We show that ethanol does not cause detectable oxidative stress in the liver at any time point and acts by promoting H-ras mutated cells.

published proceedings

  • Cancer Lett

author list (cited authors)

  • Jeannot, E., Pogribny, I. P., Beland, F. A., & Rusyn, I.

citation count

  • 6

complete list of authors

  • Jeannot, Emmanuelle||Pogribny, Igor P||Beland, Frederick A||Rusyn, Ivan

publication date

  • February 2011