Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. Academic Article

abstract

• Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of microRNAs in the pathogenesis of HCC. It also emphasizes that identification of the underlying epigenetic alterations that drive cell transformation and promote development and progression of HCC is crucially important for understanding mechanisms of hepatocarcinogenesis, its detection, therapeutic intervention, and prevention.

authors

• Rusyn, Ivan

published proceedings

• Cancer Lett

author list (cited authors)

• Pogribny, I. P., & Rusyn, I.

citation count

• 142

complete list of authors

• Pogribny, Igor P||Rusyn, Ivan

publication date

• January 2014

publisher

• Elsevier  Publisher

published in

• Cancer Letters  Journal

keywords

• Animals
• Biomarkers, Tumor
• Carcinoma, Hepatocellular
• Cell Transformation, Neoplastic
• DNA Methylation
• Disease Progression
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition To Disease
• Genetic Testing
• Hepatocellular Carcinoma
• Histone Modifications
• Histones
• Humans
• Liver Neoplasms
• Liver Neoplasms, Experimental
• MicroRNAs
• Phenotype
• Predictive Value Of Tests
• Prognosis

PubMed Central ID

• 22306342

Digital Object Identifier (DOI)

• 10.1016/j.canlet.2012.01.038

start page

• 223

end page

• 230

volume

• 342

issue

• 2

URL

• http://dx.doi.org/10.1016/j.canlet.2012.01.038

user-defined tag

• 3 Good Health and Well-Being