Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? Academic Article uri icon

abstract

  • Hepatitis C virus (HCV) is a cause of liver diseases that range from steatohepatitis, to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The challenge of understanding the pathogenesis of HCV-associated liver cancer is difficult as most standard animal models used in biomedical research are not permissive to HCV infection. Herein, we provide an overview of a number of creative in vivo, mostly in the mouse, and in vitro models that have been developed to advance our understanding of the molecular and cellular effects of HCV on the liver, specifically with their relevance to HCC.

published proceedings

  • Cancer Lett

altmetric score

  • 3

author list (cited authors)

  • Rusyn, I., & Lemon, S. M.

citation count

  • 48

complete list of authors

  • Rusyn, Ivan||Lemon, Stanley M

publication date

  • April 2014