Perimenstrual Seizures and Neurosteroid Withdrawal Chapter uri icon

abstract

  • 2017 Elsevier Inc. All rights reserved. Catamenial epilepsy is a gender-specific condition in which epileptic seizures are clustered most often around perimenstrual or periovulatory period. Perimenstrual seizure exacerbation is thought to be due to neurosteroid withdrawal at the time of menstruation. A few rodent paradigms are designed to model neurosteroid withdrawal and perimenstrual seizures. The validation is mostly based on responses to antiepileptic drugs and neurosteroid sensitivity. These rodent models are helpful to define the molecular mechanisms of perimenstrual seizures and to screen new therapeutic agents for the treatment or prevention of catamenial seizures.

author list (cited authors)

  • Reddy, D. S.

citation count

  • 0

complete list of authors

  • Reddy, Doodipala S

Book Title

  • Models of Seizures and Epilepsy

publication date

  • January 2017