Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus. Academic Article

abstract

• Recombination between Esterase-4 and Esterase-2 in the rat was not observed in 278 backcross offspring. Es-4 is thus included within the "esterase cluster" in Linkage group V. A new map of this region was constructed and the relationship of the four esterase loci was found to be: Es-4-(9.6+/-1.6 cM)-Es-2, Es-4-(1.5+/-0.7cM)-Es-3. Homology of this region with a region of Linkage Group XVIII (Chromosome 8) of the mouse was proposed on the basis of tissue distribution, subcellular localization and response of enzymes to inhibiotrs. Specifically, rat Es-1 was suggested as the homolog of mouse Es-6. An autosomal segment comprising at least 15cM of the rat and mouse genomes appears to have remained relatively intact with respect to genetic content during rodent speciation. In addition, a new polymorphism for mouse esterase was described. The locus was designated Esterase-10 (Es-10) and proposed as the mouse homolog of human Esterase D. Linkage of Es-10 with nucleoside phosphorylase-1-(Np-1) on Chromosome 14 was established.

authors

• Womack, James

published proceedings

• Genetics

author list (cited authors)

• Womack, J. E., & Sharp, M.

citation count

• 105

complete list of authors

• Womack, JE||Sharp, M

publication date

• April 1976

publisher

• Oxford University Press (OUP)  Publisher

published in

• Genetics  Journal

keywords

• Alleles
• Animals
• Chromosome Mapping
• Chromosomes
• Electrophoresis
• Esterases
• Genes
• Genetic Linkage
• Genotype
• Mice
• Polymorphism, Genetic
• Rats
• Recombination, Genetic
• Species Specificity
• Staining And Labeling

PubMed Central ID

• 57899

Digital Object Identifier (DOI)

• 10.1093/genetics/82.4.665

start page

• 665

end page

• 675

volume

• 82

issue

• 4

URL

• http://dx.doi.org/10.1093/genetics/82.4.665