An acid phosphatase locus expressed in mouse kidney (Apk) and its genetic location on chromosome 10. Academic Article uri icon

abstract

  • A genetic locus controlling the electrophoretic mobility of an acid phosphatase in mouse kidney is described. This locus, called acid phosphatase-kidney (Apk), is not expressed in erythrocytes, liver, spleen, heart, lung, brain, skeletal muscle, stomach, or testes. The product of Apk hydrolyzes the substrate naphthol AS-MX phosphoric acid but is not active on alpha-naphthylphosphate or 4-methylumbelliferylphosphate. It is not inactivated by 50 C for 1 hr, nor is its electrophoretic mobility altered by incubation with neuraminidase. The locus is invariant among 31 inbred strains (Apka), with a variant allele (Apkm) observed only in Mus musculus molossinus. Codominant expression was observed in F1 hybrids of M. m. molossinus and inbred strains. Apk was mapped on Chr 10, near the neurological mutant waltzer (v).

published proceedings

  • Biochem Genet

author list (cited authors)

  • Womack, J. E., & Auerbach, S. B.

citation count

  • 8

complete list of authors

  • Womack, JE||Auerbach, SB

publication date

  • April 1978