Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Academic Article

abstract

• A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was established by backcross experiments in which alleles at Np-1 and Robertsonian translocations were segregating. Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9 +/- 4.0 cM)-[Np-1, Wc]-(10.2 +/- 1.9 cM)-Es-10-(15.5 +/- 3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked.

authors

• Womack, James

published proceedings

• Biochem Genet

author list (cited authors)

• Womack, J. E., Davisson, M. T., Eicher, E. M., & Kendall, D. A.

citation count

• 66

complete list of authors

• Womack, JE||Davisson, MT||Eicher, EM||Kendall, DA

publication date

• April 1977

publisher

• Springer Nature  Publisher

keywords

• Alleles
• Animals
• Chromosome Mapping
• Chromosomes
• Crosses, Genetic
• Esterases
• Female
• Genotype
• Isoenzymes
• Male
• Mice
• Mice, Inbred Strains
• Pentosyltransferases
• Purine-nucleoside Phosphorylase
• Recombination, Genetic
• Species Specificity

Digital Object Identifier (DOI)

• 10.1007/BF00484465

start page

• 347

end page

• 355

volume

• 15

issue

• 3-4

URL

• http://dx.doi.org/10.1007/bf00484465