Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to chromosome 5 markers. Academic Article

abstract

• Malate dehydrogenase is present in most mammalian tissues in both supernatant and mitochondrial forms. Although genetic variation for the supernatant form has not been observed in the mouse, electrophoretic variants caused by alleles at the mitochondrial locus (Mor-1) have been previously described. We have located this locus 11.0 +/- 2.9 cM from the beta-glucuronidase structural gene, Gus, on chromosome 5. The gene order is Hm-Pgm-1-rd-bf-Gus-Mor-1. Thus Mor-1 is presently the most distal marker on chromosome 5. Three different nuclear loci for mitochondrial enzymes (Mod-2, Got-2, and Mor-1) have now been mapped in the mouse, all on different chromosomes.

authors

• Womack, James

published proceedings

• Biochem Genet

author list (cited authors)

• Womack, J. E., Hawes, N. L., Soares, E. R., & Roderick, T. H.

citation count

• 13

complete list of authors

• Womack, JE||Hawes, NL||Soares, ER||Roderick, TH

publication date

• October 1975

publisher

• Springer Nature  Publisher

keywords

• Alleles
• Animals
• Chromosome Mapping
• Crosses, Genetic
• Female
• Genetic Linkage
• Genotype
• Glucuronidase
• Kidney
• Malate Dehydrogenase
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Mitochondria
• Recombination, Genetic

Digital Object Identifier (DOI)

• 10.1007/BF00484911

start page

• 519

end page

• 525

volume

• 13

issue

• 9-10

URL

• http://dx.doi.org/10.1007/bf00484911