Biochemical genetics of rat esterases: polymorphism, tissue expression, and linkage of four loci. Academic Article

abstract

• Two alleles at each of four esterase loci in Rattus norvegicus are described with regard to tissue expression, electrophoretic characterization, and genetic linkage. A previously described dominant gene for prealbumin serum esterase is demonstrated to exist as two codominant alleles in the genetically determined absence of the characteristic albumin esterase. The allelic composition of 16 inbred strains for four esterase genes is provided, and the heretofore ambiguous nomenclature of rat esterase genetics is standardized. Linkage of Es-1, Es-2, and Es-3 is demonstrated. Es-2 and Es-3 are tightly linked in that no recombination has been observed in 55 offspring. The same offspring demonstrated 9% recombination between Es-1 and the other two loci. 1973 Plenum Publishing Corporation.

authors

• Womack, James

published proceedings

• Biochem Genet

author list (cited authors)

• Womack, J. E.

citation count

• 50

complete list of authors

• Womack, JE

publication date

• May 1973

publisher

• Springer Nature  Publisher

keywords

• Acetates
• Alleles
• Animals
• Butyrates
• Crosses, Genetic
• Duodenum
• Electrophoresis, Starch Gel
• Esterases
• Fatty Acids
• Female
• Genes, Dominant
• Genetic Linkage
• Kidney
• Male
• Molecular Biology
• Naphthols
• Polymorphism, Genetic
• Propionates
• Rats
• Rats, Inbred Aci
• Rats, Inbred F344
• Rats, Inbred Strains
• Recombination, Genetic

Digital Object Identifier (DOI)

• 10.1007/BF00485587

start page

• 13

end page

• 24

volume

• 9

issue

• 1

URL

• http://dx.doi.org/10.1007/bf00485587