Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae. Academic Article

abstract

• The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secreted is cytotoxic with little or no hemolytic activity. This indicates that the cytotoxicity of ApxIIA is independent of its hemolytic activity.

authors

• Young, Ryland

published proceedings

• Infect Immun

altmetric score

• 6

author list (cited authors)

• Tu, A. H., Hausler, C., Young, R., & Struck, D. K.

citation count

• 4

complete list of authors

• Tu, AH||Hausler, C||Young, R||Struck, DK

publication date

• May 1994

publisher

• American Society for Microbiology  Publisher

published in

• Infection and Immunity  Journal

keywords

• Actinobacillus Pleuropneumoniae
• Animals
• Bacterial Proteins
• Bacterial Toxins
• Cattle
• Cytotoxins
• Escherichia Coli
• Hemolysin Proteins

PubMed Central ID

• 8168980

Digital Object Identifier (DOI)

• 10.1128/iai.62.5.2119-2121.1994

URI

• https://hdl.handle.net/1969.1/183827

start page

• 2119

end page

• 2121

volume

• 62

issue

• 5

URL

• http://dx.doi.org/10.1128/iai.62.5.2119-2121.1994