n320169SE Academic Article uri icon

abstract

  • Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although, mechanistic studies of palate growth and fusion have focused on growth factors such as Transforming Growth Factor -3 (Tgf3), recent studies have revealed that the ephrin family of membrane bound ligands and their receptors, the Ephs, play central roles in palatal morphogenesis, growth, and fusion. In this mini-review, we will discuss the recent findings by our group and others on the functions of ephrins in palatal development.

published proceedings

  • Front Physiol

author list (cited authors)

  • Benson, M. D., & Serrano, M. J.

publication date

  • January 1, 2012 11:11 AM