Evidence for control of nitrogen metabolism by a START-dependent mechanism in Saccharomyces cerevisiae. Academic Article uri icon


  • It is generally thought that cell growth and metabolism regulate cell division and not vice versa. Here, we examined Saccharomyces cerevisiae cells growing under conditions of continuous culture in a chemostat. We found that loss of G1 cyclins, or inactivation of the cyclin-dependent kinase Cdc28p, reduced the activity of glutamate synthase (Glt1p), a key enzyme in nitrogen assimilation. We also present evidence indicating that the G1 cyclin-dependent control of Glt1p may involve Jem1p, a DnaJ-type chaperone. Our results suggest that completion of START may be linked to nitrogen metabolism.

published proceedings

  • Mol Genet Genomics

author list (cited authors)

  • Bryan, B. A., McGrew, E., Lu, Y., & Polymenis, M.

citation count

  • 5

complete list of authors

  • Bryan, BA||McGrew, E||Lu, Y||Polymenis, M

publication date

  • January 2004