STIM-ORAI interactions that control the CRAC channel.

abstract

• The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.

published proceedings

• Curr Top Membr

altmetric score

• 3

author list (cited authors)

• Gudlur, A., Zhou, Y., & Hogan, P. G.

citation count

• 41

complete list of authors

• Gudlur, Aparna||Zhou, Yubin||Hogan, Patrick G

publisher

• Elsevier  Publisher

published in

• Current Topics in Membranes  Journal

keywords

• Amino Acid Sequence
• CRAC Channel
• Calcium
• Calcium Channels
• Calcium-Binding Proteins
• Calmodulin
• Conserved Sequence
• Crac Current
• Gating
• Humans
• Interaction
• Membrane Proteins
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Mutation, Missense
• Neoplasm Proteins
• ORAI1 Protein
• Orai1
• Orai3
• Protein
• Protein Binding
• Protein Interaction Domains And Motifs
• Protein Structure, Secondary
• STIM1
• Severe Combined Immunodeficiency
• Store-operated Calcium Entry
• Stromal Interaction Molecule 1
• Structure

PubMed Central ID

• 23890110

Digital Object Identifier (DOI)

• 10.1016/B978-0-12-407870-3.00002-0

start page

• 33

end page

• 58

volume

• 71

URL

• http://dx.doi.org/10.1016/b978-0-12-407870-3.00002-0