Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.

abstract

• Insulin/IGF-1 signaling plays a central role in control of cellular metabolism and survival, while insulin receptor substrate (IRS) protein -1 and -2 and downstream PI-3 kinaseAktFoxo1 signaling cascade play key roles in many functions of insulin/IGF-1. Dysregulation of this branch of signaling cascades may provide a mechanism for insulin resistance as we observed in cells, animals, and even humans. Targeting this branch of IRSFoxo1 signaling may provide us with fundamental strategies for drug development in the future.

authors

• Guo, Shaodong

published proceedings

• Drug Discov Today Dis Mech

author list (cited authors)

• Guo, S.

citation count

• 46

complete list of authors

• Guo, Shaodong

publication date

• June 2013

publisher

• Elsevier  Publisher

published in

• Drug Discovery Today: Disease Mechanisms  Journal

keywords

• 31 Biological Sciences
• 3101 Biochemistry And Cell Biology
• Diabetes
• Metabolic And Endocrine

PubMed Central ID

• 24015152

Digital Object Identifier (DOI)

• 10.1016/j.ddmec.2013.06.003

start page

• e27

end page

• e33

volume

• 10

issue

• 1-2

URL

• http://dx.doi.org/10.1016/j.ddmec.2013.06.003