Whither grapefruit and drug interaction? Conference Paper uri icon


  • Co-consumption of grapefruit juice with common drugs such as calcium-channel blockers leads to increased bioavailability of drugs. Furocoumarins and flavonoids have been ascribed to be the primary components of grapefruit juice responsible for enhanced bioavailability of drugs by reversible and/or irreversible inhibition of CYP3A4 enzyme and P-glycoprotein. Grapefruit juice contains several furocoumarins such as bergamottin, dihydroxybergamottin, epoxy bergamottin, GF-I-1, GF-I-4 and GF-I-6. Levels of these compounds show a considerable variation among different grapefruit varieties. Elucidation of the levels of these compounds in different juice preparations will provide information for optimizing these compounds. Knowledge of furocoumarin levels in juice and die mechanisms of their interactions are expected to help in revising the dose of costly medications if co-administered with grapefruit juice or purified compounds. © 2006 American Chemical Society.

published proceedings


author list (cited authors)

  • Girennavar, B., Poulose, S. M., Brodbelt, J. S., Jayaprakasha, G. K., Bhat, N. G., & Patil, B. S.

citation count

  • 0

complete list of authors

  • Girennavar, Basavaraj||Poulose, Shibu M||Brodbelt, Jennifer S||Jayaprakasha, Guddadarangawanahally K||Bhat, Narayan G||Patil, Bhimanagouda S

publication date

  • June 2006