Spondyloarthropathy in progressive ankylosis mice: ultrastructural features of the intervertebral disk. Academic Article

abstract

• Progressive ankylosis mice (ank/ank) spontaneously develop a joint disorder characterized by calcium hydroxyapatite deposition and bony ankylosis of the joints of the axial and the appendicular skeleton. Mice in this study were used to determine the extent of mineralization of the intervertebral disks and to determine their suitability as a model for ankylosing spondyloarthropathies. Intervertebral disks taken from affected mice from 4 to 18 weeks of age were studied by electron-microscopic, electron energy-dispersive X-ray microanalysis and selected-area electron diffraction techniques. Necrotic foci seen in light microscope studies were found to be massive accumulations of calcium hydroxyapatite crystals deposited within the extracellular matrix. Chondrocytes of older animals demonstrated what appeared to be postmortem changes and contained numerous large vacuoles.

authors

• Davis, Randall

published proceedings

• Acta Anat (Basel)

author list (cited authors)

• Sampson, H. W., Davis, R. W., & Dufner, D. C.

citation count

• 14

complete list of authors

• Sampson, HW||Davis, RW||Dufner, DC

publication date

• January 1991

publisher

• Karger Publishers  Publisher

published in

• Acta Anatomica  Journal

keywords

• Animals
• Durapatite
• Electron Probe Microanalysis
• Extracellular Matrix
• Hydroxyapatites
• Intervertebral Disc
• Mice
• Mice, Mutant Strains
• Mitochondria
• Necrosis
• Spondylitis, Ankylosing

PubMed Central ID

• 1659102

Digital Object Identifier (DOI)

• 10.1159/000147096

start page

• 36

end page

• 41

volume

• 141

issue

• 1

URL

• http://dx.doi.org/10.1159/000147096