Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Academic Article

abstract

• Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-B ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo.

authors

• Feng, Jian

published proceedings

• Nat Med

altmetric score

• 11

author list (cited authors)

• Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-Hora, M., Feng, J. Q., ... Takayanagi, H.

citation count

• 1283

complete list of authors

• Nakashima, Tomoki||Hayashi, Mikihito||Fukunaga, Takanobu||Kurata, Kosaku||Oh-Hora, Masatsugu||Feng, Jian Q||Bonewald, Lynda F||Kodama, Tatsuhiko||Wutz, Anton||Wagner, Erwin F||Penninger, Josef M||Takayanagi, Hiroshi

publication date

• September 2011

publisher

• Springer Nature  Publisher

published in

• Nature Medicine  Journal

keywords

• Animals
• Bone And Bones
• Cell Differentiation
• Femur
• Flow Cytometry
• Gene Expression Profiling
• Green Fluorescent Proteins
• Homeostasis
• Immunohistochemistry
• Mice
• Mice, Transgenic
• Osteoclasts
• Osteocytes
• Osteopetrosis
• RANK Ligand
• Real-Time Polymerase Chain Reaction
• X-ray Microtomography

PubMed Central ID

• 21909105

Digital Object Identifier (DOI)

• 10.1038/nm.2452

start page

• 1231

end page

• 1234

volume

• 17

issue

• 10

URL

• http://dx.doi.org/10.1038/nm.2452