Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation. Chapter

abstract

• The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling. This chapter focuses on the current understanding of the role of Bmpr1a in cartilage development and endochondral ossification, including formation of the mesenchymal condensation, chondrocyte differentiation and maturation, and endochondral bone development.

authors

• Feng, Jian

author list (cited authors)

• Jing, J., Hinton, R. J., & Feng, J. Q.

citation count

• 16

complete list of authors

• Jing, Junjun||Hinton, Robert J||Feng, Jian Q

Book Title

• BONE MORPHOGENIC PROTEIN

publication date

• January 2015

publisher

• Elsevier  Publisher

published in

• Vitamins and Hormones: Advances in Research and Applications  Journal

keywords

• Animals
• Articular Cartilage
• Bmpr1a
• Bone Morphogenetic Protein Receptors, Type I
• Bone Morphogenetic Proteins
• Cartilage
• Cartilage Development
• Cell Differentiation
• Cell Fate
• Chondrocytes
• Chondrogenesis
• Endochondral Bone Formation
• Growth Plate
• Humans
• Mandibular Condylar Cartilage
• Mice
• Osteogenesis
• Signal Transduction
• Temporomandibular Joint

PubMed Central ID

• 26279380

Digital Object Identifier (DOI)

• 10.1016/bs.vh.2015.06.001

International Standard Book Number (ISBN) 13

• 9780128024423

start page

• 273

end page

• 291

volume

• 99

URL

• http://dx.doi.org/10.1016/bs.vh.2015.06.001