2015 by John Wiley & Sons, Inc. All rights reserved. Minimally invasive surgery (MIS) is based on the concept of using small incisions to perform surgical procedures that have previously been performed through larger surgical access openings. The surgical technique described in this chapter is based on the Videoscope-Assisted Minimally Invasive Surgery (V-MIS) approach to minimally invasive surgery. The surgical technique for MIS using either telescopes or a glass fiber endoscope and V-MIS using a videoscope is similar in many ways. The chapter describes the detail use of a videoscope for V-MIS. The same steps can be followed for MIS using surgical telescopes or a surgical microscope. Most of the MIS and V-MIS cases reported in the periodontal literature have used either enamel matrix derivative (EMD) alone or mixed with freeze-dried demineratized cortical human bone allograft (DFDBA). Finally, different case studies are presented.