Translating metabolic exchange with imaging mass spectrometry. Academic Article

abstract

• Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor.

authors

• Straight, Paul

published proceedings

• Nat Chem Biol

altmetric score

• 4.75

author list (cited authors)

• Yang, Y., Xu, Y., Straight, P., & Dorrestein, P. C.

citation count

• 208

complete list of authors

• Yang, Yu-Liang||Xu, Yuquan||Straight, Paul||Dorrestein, Pieter C

publication date

• January 2009

publisher

• Springer Nature  Publisher

published in

• Nature Chemical Biology  Journal

keywords

• Bacillus Subtilis
• Bacterial Proteins
• Genes, Bacterial
• Mutation
• Quorum Sensing
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
• Streptomyces Coelicolor

Digital Object Identifier (DOI)

• 10.1038/nchembio.252

start page

• 885

end page

• 887

volume

• 5

issue

• 12

URL

• http://dx.doi.org/10.1038/nchembio.252