A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Academic Article uri icon

abstract

  • Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells. The clones encode a prepro peptide of 36 amino acids and a mature protein of 141 amino acids that has significant homology with parathyroid hormone in the amino-terminal region. This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism.

published proceedings

  • Science

altmetric score

  • 9.5

author list (cited authors)

  • Suva, L. J., Winslow, G. A., Wettenhall, R. E., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., ... Chen, E. Y.

citation count

  • 1095

complete list of authors

  • Suva, LJ||Winslow, GA||Wettenhall, RE||Hammonds, RG||Moseley, JM||Diefenbach-Jagger, H||Rodda, CP||Kemp, BE||Rodriguez, H||Chen, EY

publication date

  • August 1987