Intractable hypercalcaemia due to parathyroid hormone-related peptide secretion by a carcinoid tumour. Academic Article

abstract

• Hypercalcaemia, a common complication of malignancy, may result from either the lytic effect of multiple osseous metastases or the effect of tumour-derived humoral factors. Excessive secretion of parathyroid hormone-related peptide (PTHrP), a major cause of humoral hypercalcaemia of malignancy, has been incriminated as the cause of hypercalcaemia in patients with lung, breast, renal, head and neck and, occasionally, haematological malignancies. Carcinoid tumours, while frequently the source of ectopic hormone secretion, are infrequently associated with hypercalcaemia. We report the case of a 59-year-old woman with fulminant hypercalcaemia due to excessive PTHrP secretion from a hepatic carcinoid and we present the change in her serum PTHrP concentrations during infusion of a somatostatin analogue.

authors

• Suva, Larry

published proceedings

• Clin Endocrinol (Oxf)

author list (cited authors)

• Mantzoros, C. S., Suva, L. J., Moses, A. C., & Spark, R.

citation count

• 26

complete list of authors

• Mantzoros, CS||Suva, LJ||Moses, AC||Spark, R

publication date

• March 1997

publisher

• Wiley  Publisher

published in

• Clinical Endocrinology  Journal

keywords

• Antineoplastic Agents, Hormonal
• Carcinoid Tumor
• Female
• Humans
• Hypercalcemia
• Liver Neoplasms
• Middle Aged
• Neoplasm Proteins
• Octreotide
• Parathyroid Hormone
• Parathyroid Hormone-related Protein
• Proteins
• Somatostatin

PubMed Central ID

• 9156050

Digital Object Identifier (DOI)

• 10.1046/j.1365-2265.1997.1090921.x

start page

• 373

end page

• 375

volume

• 46

issue

• 3

URL

• http://dx.doi.org/10.1046/j.1365-2265.1997.1090921.x