Proteomic analysis of bone cancer: a review of current and future developments.

abstract

• The ability of sophisticated proteomic approaches to scrutinize the dynamic nature of protein expression, cellular and subcellular protein distribution, post-translational modifications, and protein-protein interactions has culminated in the identification of many potential new therapeutic targets and an abundance of cancer-related biomarkers. From a proteomics perspective, amongst the most under-studied diseases are bone cancers, such as myeloma, osteosarcoma and breast and prostate cancer bony metastases. This review focuses on the recent advances in proteomic technology that have thrust the skeletal cancer field into this exciting age of proteomics, and highlights the future work that is required to adapt this technology to specifically interrogate the skeletal consequences of malignancy.

authors

• Suva, Larry

published proceedings

• Expert Rev Proteomics

author list (cited authors)

• Bhattacharyya, S., Byrum, S., Siegel, E. R., & Suva, L. J.

citation count

• 18

complete list of authors

• Bhattacharyya, Sudeepa||Byrum, Stephanie||Siegel, Eric R||Suva, Larry J

publication date

• June 2007

publisher

• Taylor & Francis  Publisher

published in

• Expert Review of Proteomics  Journal

keywords

• Biomarkers, Tumor
• Bone Neoplasms
• Breast Neoplasms
• Female
• Forecasting
• Humans
• Male
• Prostatic Neoplasms
• Proteomics

PubMed Central ID

• 17552921

Digital Object Identifier (DOI)

• 10.1586/14789450.4.3.371

start page

• 371

end page

• 378

volume

• 4

issue

• 3

URL

• http://dx.doi.org/10.1586/14789450.4.3.371