Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus. Academic Article

abstract

• Vaccination of mice with Escherichia coli expressing Brucella Cu/Zn superoxide dismutase (SOD) [E. coli(pBSSOD)] induced a significant level of protection against virulent Brucella abortus challenge, although this level was not as high as the one reached with B. abortus vaccine strain RB51. In addition, vaccination with E. coli(pBSSOD) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a thioredoxin-Cu/Zn SOD fusion protein.

authors

• Vemulapalli, Ramesh

published proceedings

• Infect Immun

author list (cited authors)

• Oate, A. A., Vemulapalli, R., Andrews, E., Schurig, G. G., Boyle, S., & Folch, H.

citation count

• 70

complete list of authors

• Oñate, AA||Vemulapalli, R||Andrews, E||Schurig, GG||Boyle, S||Folch, H

editor list (cited editors)

• McGhee, J. R.

publication date

• February 1999

publisher

• American Society for Microbiology  Publisher

published in

• Infection and Immunity  Journal

keywords

• Animals
• Antibodies, Bacterial
• Bacterial Vaccines
• Brucella Abortus
• Brucellosis
• Cell Division
• Escherichia Coli
• Female
• Gene Expression
• Lymphocytes
• Mice
• Mice, Inbred BALB C
• Superoxide Dismutase
• Vaccination
• Vaccines, Synthetic
• Virulence

Digital Object Identifier (DOI)

• 10.1128/IAI.67.2.986-988.1999

start page

• 986

end page

• 988

volume

• 67

issue

• 2

URL

• http://dx.doi.org/10.1128/iai.67.2.986-988.1999