Recovery of jaw muscle function following injection of a myotoxic agent (lidocaine-epinephrine). Academic Article

abstract

• Intramuscular injection of 2% lidocaine hydrochloride with epinephrine (1:100,000) bilaterally into the masseter muscles of growing rats resulted in a 30% to 40% decrease in maximal stimulated bite force at 3 days following injection. By 6 days postinjection, bite force had begun to increase, but significant differences from control bite force levels were still present 15 days postinjection. By 25 days postinjection, recovery to control values was complete. These data are consistent with previously documented fiber destruction and subsequent regeneration following exposure to this and other local anesthetic agents. It is suggested that local myotoxic effects produced by the administration of such drugs may result in a transient functional deficit in the injected muscle(s) that may persist for up to 2 weeks.

authors

• Dechow, Paul

published proceedings

• Oral Surg Oral Med Oral Pathol

author list (cited authors)

• Hinton, R. J., Dechow, P. C., & Carlson, D. S.

citation count

• 3

complete list of authors

• Hinton, RJ||Dechow, PC||Carlson, DS

publication date

• January 1985

publisher

• Elsevier  Publisher

published in

• Oral surgery, oral medicine, and oral pathology  Journal

keywords

• Animals
• Bite Force
• Dental Occlusion
• Epinephrine
• Injections, Intramuscular
• Lidocaine
• Male
• Masseter Muscle
• Masticatory Muscles
• Rats
• Rats, Inbred Strains
• Time Factors

Digital Object Identifier (DOI)

• 10.1016/0030-4220(85)90160-4

start page

• 247

end page

• 251

volume

• 59

issue

• 3

URL

• http://dx.doi.org/10.1016/0030-4220(85)90160-4