Smith-Lemli-Opitz syndrome: a review, case report and dental implications. Academic Article uri icon


  • Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive developmental disorder characterized by multiple congenital malformations, dysmorphic craniofacial features, and mental impairment. SLOS is caused by a deficiency of the enzyme 7-dehydrocholesterol delta7 reductase which converts 7-dehyrocholesterol to cholesterol. This error results in elevated serum levels of 7-dehydrocholesterol and decreased levels of serum cholesterol. This article describes the clinical features and medical treatment of SLOS. A case report is included, with recommended guidelines for providing safe and comprehensive dental care for individuals with SLOS.

published proceedings

  • Spec Care Dentist

author list (cited authors)

  • Muzzin, K. B., & Harper, L. F

citation count

  • 3

complete list of authors

  • Muzzin, Kathleen B||Harper, Lisa F

publication date

  • January 2003