New bioluminescent coelenterazine derivatives with various C-6 substitutions. Academic Article uri icon

abstract

  • A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueC or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.

published proceedings

  • Org Biomol Chem

author list (cited authors)

  • Jiang, T., Yang, X., Zhou, Y., Yampolsky, I., Du, L., & Li, M.

citation count

  • 10

complete list of authors

  • Jiang, Tianyu||Yang, Xingye||Zhou, Yubin||Yampolsky, Ilia||Du, Lupei||Li, Minyong

publication date

  • August 2017