New bioluminescent coelenterazine derivatives with various C-6 substitutions
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A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueC™ or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.
author list (cited authors)
Jiang, T., Yang, X., Zhou, Y., Yampolsky, I., Du, L., & Li, M.