New bioluminescent coelenterazine derivatives with various C-6 substitutions Academic Article uri icon

abstract

  • A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueCâ„¢ or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.

author list (cited authors)

  • Jiang, T., Yang, X., Zhou, Y., Yampolsky, I., Du, L., & Li, M.

citation count

  • 6

publication date

  • January 2017