Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry Conference Paper uri icon

abstract

  • Progress in the development of ion mobility (IM) orthogonal time-of-flight (oTOF) mass spectrometry for rapid analysis of biological samples is presented. The IM-oTOF apparatus described consists of a short drift tube (1 to 15 cm) designed for ion mobility measurement in the low-field limit and a low resolution linear (20 cm) TOF mass spectrometer. Proof of concept is demonstrated by analysis of peptide mixtures generated by proteolytic digestion of proteins.

name of conference

  • Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing

published proceedings

  • ADVANCES IN NUCLEIC ACID AND PROTEIN ANALYSES, MANIPULATION, AND SEQUENCING

author list (cited authors)

  • Russell, D. H., Gillig, K. J., Stone, E., Park, Z. Y., Fuhrer, K., Gonin, M., & Schultz, A. J.

citation count

  • 2

complete list of authors

  • Russell, DH||Gillig, KJ||Stone, E||Park, ZY||Fuhrer, K||Gonin, M||Schultz, AJ

editor list (cited editors)

  • Limbach, P. A., Owicki, J. C., Raghavachari, R., & Tan, W.

publication date

  • March 2000