Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry Conference Paper

abstract

• Progress in the development of ion mobility (IM) orthogonal time-of-flight (oTOF) mass spectrometry for rapid analysis of biological samples is presented. The IM-oTOF apparatus described consists of a short drift tube (1 to 15 cm) designed for ion mobility measurement in the low-field limit and a low resolution linear (20 cm) TOF mass spectrometer. Proof of concept is demonstrated by analysis of peptide mixtures generated by proteolytic digestion of proteins.

name of conference

• Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing

authors

• Russell, David

published proceedings

• ADVANCES IN NUCLEIC ACID AND PROTEIN ANALYSES, MANIPULATION, AND SEQUENCING

author list (cited authors)

• Russell, D. H., Gillig, K. J., Stone, E., Park, Z. Y., Fuhrer, K., Gonin, M., & Schultz, A. J.

citation count

• 2

complete list of authors

• Russell, DH||Gillig, KJ||Stone, E||Park, ZY||Fuhrer, K||Gonin, M||Schultz, AJ

editor list (cited editors)

• Limbach, P. A., Owicki, J. C., Raghavachari, R., & Tan, W.

publication date

• March 2000

publisher

• SPIE, the international society for optics and photonics  Publisher

published in

• n1017-2661ISSN  Journal

keywords

• Drift Tube
• Ion Mobility
• Maldi
• Peptide/protein Mixtures
• Protein Digests
• Tof

Digital Object Identifier (DOI)

• 10.1117/12.380496

International Standard Book Number (ISBN) 10

• 0-8194-3542-2

start page

• 69

end page

• 78

volume

• 1

URL

• http://dx.doi.org/10.1117/12.380496