Anti-protein and anti-bacterial behavior of amphiphilic silicones. Academic Article uri icon


  • Silicones with improved water-driven surface hydrophilicity and anti-biofouling behavior were achieved when bulk-modified with poly(ethylene oxide) (PEO) -silane amphiphiles of varying siloxane tether length: -(EtO)3Si-(CH2)2-oligodimethylsiloxane m -block-poly(ethylene oxide)8-OCH3 (m = 0, 4, 13, 17, 24, and 30). A PEO8-silane [-(EtO)3Si-(CH2)3-PEO8-OCH3] served as a conventional PEO-silane control. To examine anti-biofouling behavior in the absence versus presence of water-driven surface restructuring, the amphiphiles and control were surface-grafted onto silicon wafers and used to bulk-modify a medical-grade silicone, respectively. While the surface-grafted PEO-control exhibited superior protein resistance, it failed to appreciably restructure to the surface-water interface of bulk-modified silicone and thus led to poor protein resistance. In contrast, the PEO-silane amphiphiles, while less protein-resistant when surface-grafted onto silicon wafers, rapidly and substantially restructured in bulk-modified silicone, exhibiting superior hydrophilicity and protein resistance. A reduction of biofilm for several strains of bacteria and a fungus was observed for silicones modified with PEO-silane amphiphiles. Longer siloxane tethers maintained surface restructuring and protein resistance while displaying the added benefit of increased transparency.

published proceedings

  • Polym Chem

altmetric score

  • 0.75

author list (cited authors)

  • Hawkins, M. L., Schott, S. S., Grigoryan, B., Rufin, M. A., Ngo, B., Vanderwal, L., Stafslien, S. J., & Grunlan, M. A.

citation count

  • 42

complete list of authors

  • Hawkins, Melissa L||Schott, Samantha S||Grigoryan, Bagrat||Rufin, Marc A||Ngo, Bryan Khai D||Vanderwal, Lyndsi||Stafslien, Shane J||Grunlan, Melissa A

publication date

  • September 2017