Inhibition of hamster buccal pouch carcinogenesis by green coffee beans. Academic Article uri icon

abstract

  • Forty female Syrian Golden hamsters were divided into two equal groups and placed on one of two diets. The hamsters in Group I received a normal chow, and the animals in Group II were given the same chow supplemented with powdered green coffee beans (20%). After the hamsters adjusted to the diets, 16 animals from each group were selected. The right buccal pouch of each of these hamsters was painted three times weekly with a 0.5% solution of 7, 12-dimethylbenz(a)anthracene (DMBA) in heavy mineral oil. The eight remaining animals, four in each group, served as controls and were treated three times weekly with heavy mineral oil. After a total of 50 treatments (16 1/2 weeks), the hamsters were killed. The animals receiving green coffee beans exhibited a significant delay in the development of DMBA-induced carcinogenesis of the buccal pouch mucosa, as determined by both visual and histologic examination.

published proceedings

  • Oral Surg Oral Med Oral Pathol

author list (cited authors)

  • Miller, E. G., Formby, W. A., Rivera-Hidalgo, F., & Wright, J. M.

citation count

  • 20

complete list of authors

  • Miller, EG||Formby, WA||Rivera-Hidalgo, F||Wright, JM

publication date

  • June 1988