C₂-chiral dinucleating ligands with a 3,6-disubstituted pyridazine core Academic Article

abstract

• Reaction of the 3,6-bis(tosyloxymethyl)pyridazine (1) with two equivalents of (1R-2S)-norephedrine or (1S-2R)-1-amino-2-indanol leads to the formation of C2-chiral dinucleating ligands containing a 3,6-disubstituted pyridazine core flanked by aminoalcohol pendant arms, namely 3,6-bis((1R-2S)-(2-hydroxy-1-methyl-2-phenyl-ethyl)aminomethyl)pyridazine (2) and 3,6-bis((1S-2R)-(2-hydroxy-indan-1-yl)aminomethyl)pyridazine (3). As shown by spectrometric titration experiments as well as ESI/MS, ligands 2 and 3 bind copper(II) cations to form dinuclear complexes. 2001 Elsevier Science Ltd. All rights reserved.

authors

• Gabbai, Francois

published proceedings

• TETRAHEDRON LETTERS

author list (cited authors)

• Picot, A., & Gabbai, F. P.

citation count

• 7

complete list of authors

• Picot, A||Gabbaiï, FP

publication date

• January 2002

publisher

• Elsevier  Publisher

keywords

• C-2-chiral
• Copper Complex
• Dinucleating Ligand 3,6-pyridazine

Digital Object Identifier (DOI)

• 10.1016/S0040-4039(01)02087-1

start page

• 11

end page

• 13

volume

• 43

issue

• 1

URL

• http://dx.doi.org/10.1016/s0040-4039(01)02087-1