Nanoengineered Colloidal Inks for 3D Bioprinting. Academic Article uri icon

abstract

  • Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces the PEG network and increases viscosity, storage modulus, and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex patterns can be printed using PEG-Laponite bioinks. The 3D bioprinted structure has similar mechanical properties compared to the as-casted structure. In addition, encapsulated cells within the PEG-Laponite bioink show high viability after bioprinting. Overall, this study introduces a new class of PEG-Laponite colloidal inks for bioprinting and cell delivery.

published proceedings

  • Langmuir

altmetric score

  • 12.6

author list (cited authors)

  • Peak, C. W., Stein, J., Gold, K. A., & Gaharwar, A. K.

citation count

  • 111

complete list of authors

  • Peak, Charles W||Stein, Jean||Gold, Karli A||Gaharwar, Akhilesh K

publication date

  • January 2018