Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.
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We deleted subunits I (cydA) and II (cydB) of the Mycobacterium tuberculosis cytochrome bd menaquinol oxidase. The resulting cydA and cydAB mutants were hypersusceptible to compounds targeting the mycobacterial bc1 menaquinol-cytochrome c oxidoreductase and exhibited bioenergetic profiles indistinguishable from strains deficient in the ABC-type transporter, CydDC, predicted to be essential for cytochrome bd assembly. These results confirm CydAB and CydDC as potential targets for drugs aimed at inhibiting a terminal respiratory oxidase implicated in pathogenesis.
Antimicrob Agents Chemother
author list (cited authors)
Moosa, A., Lamprecht, D. A., Arora, K., Barry, C. E., Boshoff, H., Ioerger, T. R., ... Warner, D. F.
complete list of authors
Moosa, Atica||Lamprecht, Dirk A||Arora, Kriti||Barry, Clifton E||Boshoff, Helena IM||Ioerger, Thomas R||Steyn, Adrie JC||Mizrahi, Valerie||Warner, Digby F