Aerosol matrix-assisted laser desorption ionization mass spectrometry.

abstract

• A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported.

authors

• Russell, David

published proceedings

• J Am Soc Mass Spectrom

author list (cited authors)

• Murray, K. K., & Russell, D. H.

citation count

• 61

complete list of authors

• Murray, KK||Russell, DH

publication date

• January 1994

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Society for Mass Spectrometry  Journal

keywords

• 0299 Other Physical Sciences

PubMed Central ID

• 24226134

Digital Object Identifier (DOI)

• 10.1016/1044-0305(94)85077-1

start page

• 1

end page

• 9

volume

• 5

issue

• 1

URL

• http://dx.doi.org/10.1016/1044-0305(94)85077-1