Aerosol matrix-assisted laser desorption ionization mass spectrometry. Academic Article uri icon


  • A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported.

published proceedings

  • J Am Soc Mass Spectrom

author list (cited authors)

  • Murray, K. K., & Russell, D. H.

citation count

  • 61

complete list of authors

  • Murray, KK||Russell, DH

publication date

  • January 1994