EVALUATION OF PULSED FAST-ATOM BOMBARDMENT IONIZATION FOR INCREASED SENSITIVITY OF TANDEM MASS-SPECTROMETRY

abstract

• The use of pulsed valves for performing fast-atom bombardment (FAB) ionization on a sector ion-beam mass spectrometer is described. The objective of this work is to establish new methods for improving the sensitivity of tandem mass spectrometry. This paper deals with the use of pulsed FAB for improving total ion yields as well as signal-to-noise ratios for collision-induced dissociation and laser-ion beam photodissociation. Pulsing the neutral gas pressure used for FAB ionization results in neutral primary beam densities much greater (by a factor of 10) than those obtainable for continuous FAB. This approach yields enhancements for total ion yields and collision-induced dissociation signals by a factor of 15, while larger gains (>28) are measured for the comparable photodissociation experiment. 1989, American Chemical Society. All rights reserved.

authors

• Russell, David

published proceedings

• ANALYTICAL CHEMISTRY

author list (cited authors)

• TECKLENBURG, R. E., CASTRO, M. E., & RUSSELL, D. H.

citation count

• 13

complete list of authors

• TECKLENBURG, RE||CASTRO, ME||RUSSELL, DH

publication date

• January 1989

publisher

• American Chemical Society (ACS)  Publisher

published in

• Analytical Chemistry  Journal

Digital Object Identifier (DOI)

• 10.1021/ac00177a015

start page

• 153

end page

• 159

volume

• 61

issue

• 2

URL

• http://dx.doi.org/10.1021/ac00177a015