AEROSOL MATRIX-ASSISTED LASER-DESORPTION IONIZATION FOR LIQUID-CHROMATOGRAPHY TIME-OF-FLIGHT MASS-SPECTROMETRY Academic Article uri icon

abstract

  • We report the application of aerosol matrix-assisted laser desorption ionization (MALDI) to liquid chromatography/ mass spectrometry (LC/MS). The aerosol MALDI experiment uses aerosol liquid introduction in conjunction with pulsed UV laser ionization to form ions from large biomolecules in solution. Mass analysis is achieved in a time-of-flight mass spectrometer. In the LC/MALDI-MS experiment, the matrix solution is combined with the column effluent in a mixing tee. LC/MALDI-MS is demonstrated for the separation of brady kinin, gramicidin S, and myoglobin. 1994, American Chemical Society. All rights reserved.

published proceedings

  • ANALYTICAL CHEMISTRY

altmetric score

  • 3

author list (cited authors)

  • MURRAY, K. K., LEWIS, T. M., BEESON, M. D., & RUSSELL, D. H.

citation count

  • 35

complete list of authors

  • MURRAY, KK||LEWIS, TM||BEESON, MD||RUSSELL, DH

publication date

  • May 1994