Aerosol matrix-assisted laser desorption ionization mass spectrometry .1. Effect of solvent on ion signal Academic Article

abstract

• The effects of methanol, ethnol, propan-2-ol and acetonitrile on the aerosol matrix-assisted laser desorption/ionization (MALDI) ion signal of bradykinin, bovine insulin and myoglobin were examined. The effect of these solvents mixed with water was also studied. The aerosol MALDI ion signal for each analyte depends on the solvent, but the solvent dependence is different for the matrices 4-nitroaniline and -cyano-4-hydroxycinnamic acid. The data suggest that matrix-analyte-solvent interactions are an important consideration for the aerosol MALDI ion signal. It appears that the ion signal is the result of a competition between solvent polarity and volatility. The solvent polarity affects matrix-analyte interactions whereas solvent volatility affects the aerosol drying process.

authors

• Russell, David

published proceedings

• JOURNAL OF MASS SPECTROMETRY

altmetric score

• 12

author list (cited authors)

• Russell, D. H., & Beeson, M. D.

citation count

• 12

complete list of authors

• Russell, DH||Beeson, MD

publication date

• March 1996

publisher

• Wiley  Publisher

keywords

• Aerosol Particles
• Liquid Introduction
• Maldi
• Mass Spectrometry
• Time-of-flight

Digital Object Identifier (DOI)

• 10.1002/(sici)1096-9888(199603)31:3<295::aid-jms297>3.0.co;2-f

start page

• 295

end page

• 302

volume

• 31

issue

• 3

URL

• http://dx.doi.org/10.1002/(sici)1096-9888(199603)31:3%3C295::aid-jms297%3E3.0.co;2-f