A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules. Academic Article uri icon

abstract

  • Chemists are constantly striving for techniques that add dimensions of orthogonality with increased throughput and sample complexity. Ion mobility spectrometry (IM) is a gas-phase separation method that adds new dimensions to mass spectrometry (MS). IM separates gas-phase ions based on their collision cross-section and can be coupled with time-of-flight (TOF) mass spectrometry to yield a powerful tool used in the identification and characterization of proteins and peptides. A fundamental introduction to IM is presented with a focus on resolution, sensitivity, and orthogonality coupled with TOF-MS.

published proceedings

  • J Biomol Tech

author list (cited authors)

  • Verbeck, G. F., Ruotolo, B. T., Sawyer, H. A., Gillig, K. J., & Russell, D. H.

citation count

  • 75

complete list of authors

  • Verbeck, Guido F||Ruotolo, Brandon T||Sawyer, Holly A||Gillig, Kent J||Russell, David H

publication date

  • June 2002