Reduced lung glutamate (GLU) production is the cause of decreased systemic glutamate availability in hyperdynamic sepsis Conference Paper uri icon


  • RATIONALEPreviously, we described in patients in the early phase of septic shock that reduced plasma GLU relates to mortality. As the mechanism is unclear, we studied GLU organ net balances (NB) in a Pseudomonas aeroginosa (PM) sepsis induced pig model.METHODSArterial GLU concentrations and transorgan GLU net balances were studied in 12 pigs with sepsis and 8 controls. GLU concentrations were determined with LCMS. Data are expressed as (mean (SE) control vs PM) in M (conc) and nmol/kg bw/min (NB), statistics with Student ttest.RESULTSIn PM pigs, arterial GLU concentration (81.3(6.8) vs 38.0(3.7)) and lung GLU net release (7472(1457) vs 1354(1204)) were reduced (resp. 53%, p<0.0001 and 82%, p=0.0088), while Liver net release was unchanged. Gut (195(49) vs 24(34)) and muscle (843(57) vs 376(73)) GLU net uptake were decreased (resp. 88%, p=0.009 and 55%, p=0.0002).CONCLUSIONThe reduced lung GLU production plays a major role in the reduced systemic GLU availability in sepsis.

published proceedings


author list (cited authors)

  • Ten Have, G. A., Engelen, M. P., Wolfe, R. R., & Deutz, N. E.

citation count

  • 1

complete list of authors

  • Ten Have, Gabriella A||Engelen, Marielle P||Wolfe, Robert R||Deutz, Nicolaas E

publication date

  • April 2012