Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol. Academic Article uri icon


  • BACKGROUND: Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss. METHODS/DESIGN: In a randomized controlled trial 70 participants with stable CAD, age 45-75, body mass index 28-40kg/m2 and no diabetes are randomized (1:1) to 12weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO2peak 3 times weekly for 12weeks followed by supervised AIT twice weekly for 40weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800-1000kcal/day) for 12weeks, followed by 40weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12weeks' intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures. DISCUSSION: The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD. TRIAL REGISTRATION: NCT01724567.

published proceedings

  • BMC Cardiovasc Disord

author list (cited authors)

  • Pedersen, L. R., Olsen, R. H., Frederiksen, M., Astrup, A., Chabanova, E., Hasbak, P., ... Prescott, E.

citation count

  • 12

complete list of authors

  • Pedersen, Lene Rørholm||Olsen, Rasmus Huan||Frederiksen, Marianne||Astrup, Arne||Chabanova, Elizaveta||Hasbak, Philip||Holst, Jens Juul||Kjær, Andreas||Newman, John W||Walzem, Rosemary||Wisløff, Ulrik||Sajadieh, Ahmad||Haugaard, Steen Bendix||Prescott, Eva

publication date

  • November 2013