Cost of speed: A practical approach to evaluate a screening method from a Bayesian perspective uri icon

abstract

  • 2016 Elsevier B.V. Utilization of rapid screening method presents an investment decision of laboratory assets. Screening methods are filtering procedures implemented to enable analysis of a large volume of samples in a rapid fashion. The principle of screening includes establishment of a threshold value as a selection criteria for the follow up confirmative analysis. Selection of a quality screening method determines the optimized utilization of laboratory resources. Two mathematical models are used to evaluate a screening method by directly comparing to a gold standard reference method. The first model utilizes the traditional receiver operating characteristic (ROC) curve model to evaluate the screening method. A new model is proposed to access the accuracy and reliability of the screening method based on the gold standard reference method. The two models are extremely practical for a single laboratory to evaluate the reliability of a screening method when limited resources are available.

published proceedings

  • CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

author list (cited authors)

  • Dai, S. Y., Sang, H., Lee, K., & Herrman, T. J.

citation count

  • 1

complete list of authors

  • Dai, Susie Y||Sang, Huiyan||Lee, Kyung-Min||Herrman, Timothy J

publication date

  • January 2016