Physiological alterations associated with intrauterine growth restriction in fetal pigs: Causes and insights for nutritional optimization. Academic Article uri icon


  • Intrauterine growth restriction (IUGR) remains a major problem in swine production since the associated low birth weight leads to high rates of pre-weaning morbidity and mortality plus permanent retardation of growth and development. Complex biological events-including genetics, epigenetics, maternal maturity, maternal nutrition, placenta efficiency, uterine capacity, and other environmental factors-can affect fetal growth and development during late gestation, as well as maturity of oocytes, duration of estrus, and both implantation and placentation of conceptuses in uteri of sows. Understanding the physiological changes related to initiation and progress of IUGR are, therefore, of great importance to formulate nutritional strategies that can mitigate IUGR in gilts and sows. Altering the nutritional status of sows prior to mating and during early-, mid-, and late-gestation may be effective at increasing the uniformity of oocytes and conceptuses, decreasing variation among conceptuses during elongation and implantation, and preventing increases in within-litter variation in fetal weights during late gestation. This review summarizes current progress on physiological alterations responsible for IUGR fetuses, as well as possible nutritional interventions to prevent the initiation and continuation of IUGR in gilts and sows.

published proceedings

  • Mol Reprod Dev

author list (cited authors)

  • Wang, J., Feng, C., Liu, T., Shi, M., Wu, G., & Bazer, F. W.

citation count

  • 51

complete list of authors

  • Wang, Junjun||Feng, Cuiping||Liu, Ting||Shi, Meng||Wu, Guoyao||Bazer, Fuller W

publication date

  • September 2017