The Effects of the [latin sharp s]2-Agonist Clenbuterol, and Exercise Training on Muscle Protein and Performance in Frogs.
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The effects of exercise training and clenbuterol on the exercise performance and muscle morphology of 69 adult male Northern grass frogs were compared. Frogs were randomly assigned to 1 of 4 groups: control (C), exercise (Ex), drug (Dr), and exercise + drug (Ex + Dr). Groups were tested before and after 6 weeks of treadmill training to evaluate treadmill exercise capacity (no. of hops) and force production during jumps. Data were analyzed with one-way MANOVAs (p < 0.05). Ex performed more hops than the other groups. In regard to force output, however, that of Dr was significantly greater that that of the other groups. For gastrocnemius weight, that of C was significantly less than for the other groups while that of Dr was significantly greater than Ex and Ex + Dr. Total muscle protein content showed no significant differences; myofibrillar protein content showed that Ex and Dr, though not significantly different from each other, were superior to C and Ex + Dr. This may suggest that clenbuterol and exercise, when combined, may impede muscle growth and performance. © 1996 Lippincott Williams & Wilkins, Inc.
author list (cited authors)
Willoughby, D. S., Barnes, W. S., Ingalls, C. P., & Smith, S. B.