A comparison of MALDI and ESI for analysis of dirhodium-DNA adducts Conference Paper uri icon

abstract

  • A comparison of matrix-assisted laser desorption ionization (MALDI) and nanoelectrospray (nanoESI) for analysis of dirhodium-DNA adducts is discussed. MALDI and nanoESI coupled to time-of-flight mass spectrometry (TOFMS) are used to characterize the products and relative rates of reactivity for DNA oligonucleotides with platinum or dirhodium complexes. In DNA-platinum reactions, only one final product is observed by MALDI MS and ESI MS: the addition of diamminoplatinum to the DNA oligonucleotide. The formation of this platinated oligonucleotide can be monitored by comparison of its ion signal intensity to that of the unreacted DNA oligonucleotide.

published proceedings

  • Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics

author list (cited authors)

  • Koomen, J. M., Kang, M., Chifotides, H., Dunbar, K. R., & Russell, D. H.

complete list of authors

  • Koomen, JM||Kang, M||Chifotides, H||Dunbar, KR||Russell, DH

publication date

  • December 2002