Reactivities and biological functions of iron-sulfur clusters Academic Article uri icon


  • Iron-sulfur clusters are prevalent in biological systems. Through studies of iron-sulfur proteins and synthetic model clusters, it was realized early on that these clusters functioned as facile electron transfer agents. Until recently it was widely thought that they served exclusively in that capacity. However, in the last decade, it has become clear that their reactivities and biological functions are much more diverse. It is now apparent that these clusters can serve as the active sites of enzymes, as well as in the regulation of enzymatic activity. Synthetic clusters, which have been shown to undergo a variety of core rearrangements or structural changes, have provided insight into possible mechanisms of cluster formation or activity regulation in enzymes. Rigid tripodal ligands have been constructed which capture synthetic iron-sulfur clusters in a cavity which permits controlled reactivity studies. In this article, we review these recent developments and suggest some future directions the field may take. 1990 Plenum Publishing Corporation.

published proceedings

  • Journal of Cluster Science

author list (cited authors)

  • Lindahl, P. A., & Kovacs, J. A.

citation count

  • 28

complete list of authors

  • Lindahl, Paul A||Kovacs, Julie A

publication date

  • January 1990