Radiofluorination of a NHC-PF5 adduct: toward new probes for 18F PET imaging.
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The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(v) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted 18F-19F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.
author list (cited authors)
Vabre, B., Chansaenpak, K., Wang, M., Wang, H., Li, Z., & Gabbai, F. P.
complete list of authors
Vabre, Boris||Chansaenpak, Kantapat||Wang, Mengzhe||Wang, Hui||Li, Zibo||Gabbaiï, François P