Radiofluorination of a NHC-PF5 adduct: toward new probes for 18F PET imaging. Academic Article uri icon


  • The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(v) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted 18F-19F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.

published proceedings

  • Chem Commun (Camb)

altmetric score

  • 4.6

author list (cited authors)

  • Vabre, B., Chansaenpak, K., Wang, M., Wang, H., Li, Z., & Gabbai, F. P.

citation count

  • 15

complete list of authors

  • Vabre, Boris||Chansaenpak, Kantapat||Wang, Mengzhe||Wang, Hui||Li, Zibo||Gabbaiï, François P

publication date

  • August 2017